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Abstract The global cost of diabetes care exceeds $1 trillion each year with more than $327 billion being spent in the United States alone. Despite some of the advances in diabetes care including continuous glucose monitoring systems and insulin pumps, the technology associated with managing diabetes has largely remained unchanged over the past several decades. With the rise of wearable electronics and novel functional materials, the field is well‐poised for the next generation of closed‐loop diabetes care. Wearable glucose sensors implanted within diverse platforms including skin or on‐tooth tattoos, skin‐mounted patches, eyeglasses, contact lenses, fabrics, mouthguards, and pacifiers have enabled noninvasive, unobtrusive, and real‐time analysis of glucose excursions in ambulatory care settings. These wearable glucose sensors can be integrated with implantable drug delivery systems, including an insulin pump, glucose responsive insulin release implant, and islets transplantation, to form self‐regulating closed‐loop systems. This review article encompasses the emerging trends and latest innovations of wearable glucose monitoring and implantable insulin delivery technologies for diabetes management with a focus on their advanced materials and construction. Perspectives on the current unmet challenges of these strategies are also discussed to motivate future technological development toward improved patient care in diabetes management. 

Abstract Increasing demand for wearable healthcare synergistically advances the field of electronic textiles, or e‐textiles, allowing for ambulatory monitoring of vital health signals. Despite great promise, the pragmatic deployment of e‐textiles in clinical practice remains challenged due to the lack of a method in producing custom‐designed e‐textiles at high spatial resolution across a large area. To this end, a programmable dual‐regime spray that enables the direct custom writing of functional nanoparticles into arbitrary fabrics at sub‐millimeter resolution over meter scale is employed. The resulting e‐textiles retain the intrinsic fabric properties in terms of mechanical flexibility, water‐vapor permeability, and comfort against multiple uses and laundry cycles. The e‐textiles tightly fit various body sizes and shapes to support the high‐fidelity recording of physiological and electrophysiological signals on the skin under ambulatory conditions. Pilot field tests in a remote health‐monitoring setting with a large animal, such as a horse, demonstrate the scalability and utility of the e‐textiles beyond conventional devices. This approach will be suitable for the rapid prototyping of custom e‐textiles tailored to meet various clinical needs.